Combination ‘polypill’ lowers the risk of major cardiovascular events, study finds

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CNN

According to a new study published Friday in the New England Journal of Medicine and presented at the European Society of Cardiology Congress in November, elderly patients with heart disease who took a combination “polypill” consisting of three different drugs, a lower risk of major cardiovascular events. Spain.

Study authors led by Dr. Valentin Fuster, director of Mount Sinai Heart in New York City and general manager of the Spanish National Center for Cardiovascular Research, looked at 2,499 patients in seven European countries who had a history of type 1 myocardial infarction six months and older than 75 years of age. at least 65 years of age with at least one risk factor, such as diabetes or mild or moderate renal impairment.

Half of the patients received the polypill containing aspirin, ramipril and atorvastatin, while others received usual care. Patients were followed for a median of three years.

The researchers found 48 cardiovascular deaths in the polypill group and 71 in the usual care group, meaning that patients taking the polypill had a 33% relative risk reduction in cardiovascular death. The polypill was also beneficial in other measures examined in the study, such as stroke or myocardial infarction.

The polypill and trial come after 15 years of work, Fuster said. He and colleagues concluded that one of the biggest problems in medicine is the lack of adherence to the medications they have to take, particularly in the cardiovascular field and especially in heart attack patients.

The American Heart Association lists taking medications as prescribed as one of the first things people can do to prevent another heart attack after they have one.

“It looks like we have a great kind of tool, a simple polypill, which is actually significantly better,” Fuster said. “Probably most of the reason is because of better adherence, because it’s a simple drug, with excellent results, and the impact is as good or even better than aspirin in the past.”

He said it was notable that the two curves — those who took a polypill and those who received standard care — separated from the start and continued to separate over the years, meaning there’s a sense that the study will last longer. would last. “even more striking” results.

Fuster said the polypill is something that could have a “very significant” effect on the general population.

According to the US Centers for Diseases Control and Prevention, someone in the US has a heart attack every 40 seconds. There are about 805,000 heart attacks in the country each year – 200,000 of those happen to people who have already had one.

There are some limitations to the study, including that the trial was not conducted in a blinded manner and that all patients were enrolled before the Covid-19 pandemic.

The Valley Voice
The Valley Voicehttp://thevalleyvoice.org
Christopher Brito is a social media producer and trending writer for The Valley Voice, with a focus on sports and stories related to race and culture.

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