Overview: Consuming green vegetables and adding a daily chlorophyllin supplement helps relieve symptoms of inflammatory bowel disease, researchers report. In addition, chlorophyllin supplements help significantly reduce the mortality risks associated with IBD.
The dietary supplement chlorophyllin relieves inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, according to researchers at the Center for Diabetes and Metabolism Research at Sichuan University in China and Cedars Sinai Medical Center in Los Angeles.
In addition, chlorophyllin significantly reduces mortality related to IBD, weight loss, diarrhea and hidden blood in the stool, intestinal epithelial damage and inflammatory cell infiltration.
The findings will be published in the American Journal of Physiology-Gastrointestinal and Liver Physiologyand the study was chosen as the APS select article for August.
Chronic gastrointestinal diseases such as IBD affect tens of millions of people living in the US. IBD has created a global health burden due to the rising cost of treating the condition.
While the exact cause of IBD is not fully understood, some contributing factors include stress and environmental, lifestyle, and dietary choices, such as high consumption of meat or fish.
Chronic inflammation, abnormality in autophagy — the body’s process of clearing damaged cells to make way for newer, healthier cells — and lysosomal stress (an abnormality in an organelle that leads to inflammation) have also been linked to the condition.
Current therapies for IBD include drugs that suppress the immune system (immunosuppressants) and surgery. However, long-term use of immunosuppressive treatments can lead to serious side effects, including opportunistic infections and even organ failure.
In this study, researchers found that taking an oral chlorophyllin supplement — a compound derived from the green pigment found in plants — reduced colitis and abnormalities in the intestinal epithelium of mice.
Also, consumption of green vegetables and chlorophyllin may be helpful for IBD recovery, in part by alleviating inflammation and autolysosomal flux (a process that uses lysosome to break down and remove toxic molecules and organelles).
Green pigment found in these foods and supplements can initiate a nutritional signal to modulate autophagy in the cells, which suppresses IBD symptoms.
Researchers believe these findings could lead to a less invasive treatment for IBD.
“Consuming green-colored vegetables or green pigment supplements like chlorophyllin may help people with inflammatory bowel disease,” says Xiaofeng Zheng, Ph.D., of Sichuan University and a co-author of the study.
About this Nutrition and Inflammation Research News
Author: press office
Contact: Press agency – APS
Image: The image is in the public domain
Original research: Open access.
“Liver-on-a-chip devices: the advantages and disadvantages of complexity” by Philip Dalsbecker et al. American Journal of Physiology-Gastrointestinal and Liver Physiology
Deliver-on-a-chip devices: the pros and cons of complexity
Physiologically relevant and broadly applicable liver cell culture platforms are of great importance in both drug development and disease modelling.
Organ-on-a-chip systems offer a promising alternative to conventional, static two-dimensional (2-D) cultures, with much-needed signals such as perfusion, shear stress and three-dimensional (3-D) cell-cell communication.
However, such devices cover a wide range of complexity, both in manufacture and execution. In this review, we summarize key features of the human liver to be reflected in a physiologically relevant liver-on-a-chip model.
We also discuss various material properties important in producing liver-on-a-chip devices and summarize recent and current advances in the field, highlighting different types of devices at different levels of complexity.